Effectiveness of Water Extract of Sea Lettuce (Ulva Lactuca) from Aceh to Reduce Blood Glucose Levels in Diabetic Rats

Rinawati Rinawati, Sri Wahyuni Muhsin, Hanif Muchdatul Ayunda

Abstract


Diabetes mellitus (DM) is a non-communicable disease characterized by high blood glucose levels caused by damage to the pancreas, which cannot produce insulin. Antidiabetic drugs and insulin injections in the long term have specific side effects, so herbal medicine is considered safer to use. Sea lettuce (Ulva lactuca) is one of the herbal medicines that have the potential as an antidiabetic. Methods: Experimental using a completely randomized design. Rats were divided into five groups with three replicates, namely: Kn = normal control, Ka = STZ control, P1 = DM rats + 200 mg/KgBB extract dose, P2 = DM rats + 300 mg/KgBB extract dose, and P3 = DM rats + 400 mg/KgBB extract dose. The stages of this study began with the preparation of tools and materials, phytochemical tests, the preparation of test animals and testing extracts on test animals, and the measurement of blood glucose levels in rats before and after they were given extracts. Blood glucose levels were measured using a glucometer. Data analysis was performed statistically (ANOVA). The results of the phytochemical tests detected were steroids, saponins, and phenols/tannins, while alkaloids, terpenoids, and flavonoids were not. The most effective blood glucose level measurement result is at a dose of 400 mg/KgBB.

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Agus, Rheza Paleva. "Mekanisme Resistensi Insulin Terkait Obesitas." Jurnal Ilmiah Kesehatan Sandi Husada 8.2 (2019): 354-358.

Andlib, Nida, et al. "Abnormalities in sex hormones and sexual dysfunction in males with diabetes mellitus: A mechanistic insight." Acta Histochemica 125.1 (2023): 151974.

Appu, Anoop, et al. "Injectable chitosan-Ulva lactuca polysaccharide hydrogel neutralizes oxidative stress in experimental diabetic neuropathy." GSC Biological and Pharmaceutical Sciences 21.1 (2022): 042-059.

Arbi, Basyrowi, Widodo Farid Ma’ruf, and Romadhon Romadhon. "AKTIVITAS SENYAWA BIOAKTIF SELADA LAUT (Ulva lactuca) SEBAGAI ANTIOKSIDAN PADA MINYAK IKAN" Saintek Perikanan: Indonesian Journal of Fisheries Science and Technology” Vol 12 No 1. 2016: 12-18.

Chen, Y., e. al, “Regulatory Mechanisms Of The Green Alga Ulva Lactuca Oligosaccharide Via The Metabolomics And Gut Microbiome In Diabetic Mice”. Current Research In Food Science, Volume 5, 14 July 2022: 1127-1139.

Chen, Yihan, et al. "Regulatory mechanisms of the green alga Ulva lactuca oligosaccharide via the metabolomics and gut microbiome in diabetic mice." Current Research in Food Science 5 (2022): 1127-1139.

Da Costa, Junet Franzisca, Windu Merdekawati, and Ferly Rambu Otu. "Analisis Proksimat, Aktivitas Antioksidan, Dan Komposisi Pigmen Ulva Lactuca L. Dari Perairan Pantai Kukup." Jurnal Teknologi Pangan dan Gizi 17.1 (2018): 1-17.

Departemen Kesehatan Republik Indonesia. 2007. Keputusan Menteri Kesehatan Republik Indonesia Nomor 381 Tahun 2007 tentang Kebijakan Obat Tradisional Nasional Tahun 2007. Jakarta: Depkes RI.

Ditasari, Ulvi, Agung Giri Samudra, and Reza Pertiwi. "EFEKTIVITAS ANTIHIPERGLIKEMIA EKSTRAK ETANOL Ulva sp. DAN Sargassum sp. PADA MENCIT YANG DIINDUKSI SUKROSA: ANTIHYPERGLYCHEMIC EFFECTIVENESS OF ETHANOL EXTRACT Ulva sp. AND Sargassum sp. IN SUCROSE-INDUCED MICULES." Medical Sains: Jurnal Ilmiah Kefarmasian 7.4 (2022): 789-796.

Dyahnugra, A.A dan Widjarnato, S.B. “Pemberian Ekstrak Bubuk Simplasia kulit manggis (Garcinia Mangostana L) Menurunkan Kadar Glukosa Pada Tikus Putih (Rattus norvegicus) Strain Wistar Jantan Kondisi Hiperglikemik”. Jurnal publikasi. Volume 3, No 1. 2015: 122

Guzmán, David Calderón, et al. "Consumption of cooked common beans or saponins could reduce the risk of diabetic complications." Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 13 (2020): 3481.

Hesturini, Rosa Juwita, et al. "ANALGESIC TEST AND TOXICITY OF n-HEXANA FRACTION TREMBESI LEAVES (Samanea saman (Jacq.) Merr.) IN MICE (Mus musculus L.)." Jurnal Farmasi Sains dan Praktis (2022): 32-41.

Jiang, Shuang, et al. "Antidiabetic effect of Momordica charantia saponins in rats induced by high-fat diet combined with STZ." Electronic Journal of Biotechnology 43 (2020): 41-47.

Latifa, Nabila Nur, Lanny Mulqie, and Siti Hazar. "Penetapan Kadar Sari Larut Air Dan Kadar Sari Larut Etanol Simplisia Buah Tin (Ficus carica L.)." Bandung Conference Series: Pharmacy. Vol. 2. No. 2. 2022.

Munawwaroh, Siti Winda, Sri Peni Fitrianingsih, and Ratu Choesrina. "Studi Literatur Aktivitas Antidiabetes Biji Mahoni (Swietenia mahagoni (L.) Jacq.)." Bandung Conference Series: Pharmacy. Vol. 2. No. 2. 2022.

Murugesan, S., Anand, B.M., Bhuvaneswari, S., Kotteswari, M., andThennarasan, S.”In vitro Antidiabetic Activity of Methanolic Extracts of Selected Marine Algae”. European Journal of Pharmaceutical and Medical Research. Volume 2, No.6. 2015: 256-260.

Nilsson, Peter M., and Andrea Natali. "Insulin and Blood Pressure Relationships." Blood Pressure Disorders in Diabetes Mellitus. Springer, Cham, 2023. 119-128.

Novalinda, Novalinda, Mukti Priastomo, and Laode Rijai. "Literature Review: Bahan Alam yang Berpotensi sebagai Antidiabetes: Literature Review: Natural Ingredients that Have Potential as Antidiabetic." Proceeding of Mulawarman Pharmaceuticals Conferences. Vol. 14. 2021.

Nur’Afni Oktaviana Buhang, Siti Nuryanti, and Daud Karel Walanda. "UJI AKTIVITAS ANTIOKSIDAN EKSTRAK BAYAM MERAH (BLITUM RUBRUM) DALAM PELARUT ETANOL DAN AIR DENGAN PEREAKSI DPPH."

Pasaribu, Fidayani, Panal Sitorus, and Saiful Bahri. "Uji ekstrak etanol kulit buah manggis (Garcinia mangostana L.) terhadap penurunan kadar glukosa darah." Journal of Pharmaceutics and Pharmacology 1.1 (2012): 1-8.

Pop-Busui, Rodica, et al. "Heart failure: an underappreciated complication of diabetes. A consensus report of the American Diabetes Association." Diabetes Care 45.7 (2022): 1670-1690.

Port, M.C. “Pathofiology Concep Of Altered Healt Status Second Edition”. Lipincot Company. Phyladelpia. 1995:120-123

Prisdiany, Yulin, et al. "Potensi Tanaman Herbal Antidiabetes untuk Minuman Obat: Sebuah Literatur Review." Indonesian Journal of Clinical Pharmacy 10.2 (2021): 144-158.

Resti, Intan Apri, and Hesty Parbuntari. "Identifikasi Senyawa Metabolit Sekunder Ekstrak Jamur Tiram Putih (Pleurotus ostreatus L.)." Periodic 11.2 (2022): 65-69.

Rinawati, Rinawati, E. Suharyanto, and Nastiti Wijayanti. "Pengaruh Ekstrak Rebusan Daun Tithonia diversifolia (Hemsl.) A. Gray Terhadap Kadar Glukosa Darah." BIOTIK: Jurnal Ilmiah Biologi Teknologi dan Kependidikan 7.1 (2019): 41-48.

Rinawati, Rinawati, Sri Wahyuni Muhsin, and Siti Maisyaroh Fitri Siregar. "Pengaruh Ekstrak Air Selada Laut (Ulva Lactuca) Terhadap Berat Badan Pada Tikus Diabetes." STIGMA: Jurnal Matematika dan Ilmu Pengetahuan Alam Unipa 13.01 (2020): 39-46.

Saeedi, Pouya, et al. "Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas." Diabetes research and clinical practice 157 (2019): 107843.

Setiawan, B dan Suhartono, E. 2005. Stres Oksidatif dan Peran Antioksidan pada Diabetes Melitus. Majalah Kedokteran Indonesia. 55(2):87

Suryandari, Mercyska, and Galuh Gondo Kusumo. "Identifikasi Senyawa metabolit Sekunder Ekstrak Kulit Bawang Merah (Allium cepa L.) dari Berbagai Macam Pelarut." Journal Pharmasci (Journal of Pharmacy and Science) 7.2 (2022).

Suryani, Nany. "Pengaruh Ekstrak Metanol Biji Mahoni terhadap Peningkatan Kadar Insulin, Penurunan Ekspresi TNF-αdan Perbaikan Jaringan Pankreas Tikus Diabetes." Jurnal kedokteran brawijaya 27.3 (2013): 137-145.

Tair, Z. I., F. Bensalah, and F. Boukortt. "Effect of green alga Ulva lactuca polysaccharides supplementation on blood pressure and on atherogenic risk factors, in rats fed a high fat diet." Annales de cardiologie et d'angeiologie. Vol. 67. No. 3. 2018

Tandi, Joni, Tien Wahyu Handayani, and Agustinus Widodo. "Qualitative And Quantitative Determination Of Secondary Metabolites And Antidiabetic Potential Of Ocimum Basilicum L. Leaves Extract." RASĀYAN J. Chem 14.1 (2021): 622-628.

Thongsom, Montakarn, et al. "Antioxidant and hypoglycemic effects of Tithonia diversifolia aqueous leaves extract in alloxan-induced diabetic mice." Advances in Environmental Biology (2013): 2116-2126.

Touyz, Rhian M., et al. "Molecular Mechanisms Underlying Vascular Disease in Diabetes." Blood Pressure Disorders in Diabetes Mellitus. Springer, Cham, 2023. 105-118.

Whiting, David R., et al. "IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030." Diabetes research and clinical practice 94.3 (2011): 311-321.

WHO. 2018. Prevention of Diabetes Mellitus. Technical Report Series. Geneva.

Zahra, Hafizh, et al. "Aktivitas Antiulseratif Berbagai Tanaman Herbal dan Prospek Masa Depan Sebagai Tanaman Budidaya: Anti-ulceritis Activity of Various Herbal Plants and Future Prospects as Cultivated Plants." Jurnal Sains dan Kesehatan (J. Sains Kes.) 4.3 (2022): 343-353.

Zulfadhli, Zulfadhli, and Rinawati Rinawati. "Potensi Selada Laut Ulva lactuca Sebagai Antifungi Dalam Pengendalian Infeksi Saprolegnia Dan Achlya Pada Budidaya Ikan Kerling (Tor sp)." Jurnal Perikanan Tropis 5.2 (2018): 183-188.




DOI: https://doi.org/10.35308/jns.v3i2.6833

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